This latest research paves the way for new systems to detect changes in reactive oxygen levels which could help target interventions. Mapped using fluorescent imaging, the concentration of reactive oxygen in cells and tissue would light up which will help better understand and monitor disease development and intervention. Using fluorescence probes it will be possible to perform whole body imaging, making it is possible to monitor insitu tumour development in real-time.
Professor Tony James from the University of Bath’s Department of Chemistry commented: “I am very excited by these new results which have pointed our research in an unexpected yet truly rewarding direction. This work uses ‘simple’ molecules which are capable of helping doctors understand and diagnose ‘difficult’ diseases.”
This latest paper has been supported by the Catalysis and Sensing for our Environment (CASE) network between researchers at the Universities of Bath, Birmingham and Shanghai.
Dr John Fossey from the University of Birmingham added: “This most recent project has taken the international CASE consortium in a different and exciting direction. Developing a new sensing model based on reactive oxygen has many useful applications in diagnosing and detecting disease.”
The latest paper about reactive oxygen is just one of two articles from the CASE network published in this month’s ChemComm. The other paper focuses on new sensing systems to measure the purity of molecules which may have important applications in drug development.
For more see ‘International CASE collaboration delivers two major publications’.
To download the research papers see:
“Integrated” and “insulated” boronate-based fluorescent probes for the detection of hydrogen peroxide – http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/c3cc43265c
Colorimetric enantioselective recognition of chiral secondary alcohols via hydrogen bonding to a chiral metallocene containing chemosensor - http://pubs.rsc.org/en/Content/ArticleLanding/2013/CC/c3cc43083a
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